Intellectual Property Rights in the U.S

XSpray strengthens patent portfolio for breakthrough particle production technology  November 4, 2010 – 09:27 am
Intellectual Property Rights

Stockholm, Sweden – November 04, 2010. XSpray Microparticles today announced that the US Patent and Trademark Office has granted a patent relating to the company’s particle production technology. XSpray’s RightSize™ technology provides complete control over particle production, enhancing drug formulation options and optimizing the performance of challenging drug substances, such as poorly soluble compounds, inhaled compounds, and biomolecules.

The technology uses supercritical fluid (SCF) as an antisolvent for controlled precipitation of an active pharmaceutical ingredient/drug substance. The new patent approval covers both design and method patents relating to XSpray’s unique nozzle head, where precipitation of the drug substance takes place.

The breakthrough design enables reproducible production of small particles of specific sizes, required for the development of inhalable drugs. It also enables nanoparticles to be produced with a consistent particle size below 200 nm. The technology is compatible with a wide range of excipients. These can, for example, be added to increase stability and/or wettability in amounts from >50% down to trace amounts.

The dimensions of the actual fluid mixing and spray forming regions are kept constant at all scales. This means the technology can be effectively scaled up to drug manufacturing volumes. Consistent high-quality particles are produced, with full control over particle size, size distribution and polymorph, irrespective of production scale.

Source: XSpray Microparticles

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